Basic Information
| LncRNA/CircRNA Name | XIST |
| Synonyms | NA |
| Region | GRCh38_X:73820651-73852753 |
| Ensemble | ENSG00000229807 |
| Refseq | NR_001564 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic cancer |
| ICD-0-3 | C25 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , in vitro knockdown etc. |
| Sample | Human PC tissues and the matched non-tumor normal tissues ,PC cell lines (ASPC-1, PANC-1, HPAC, BxPC-3, CFPAC-1) ,human pancreatic ductal epithelial (HPDE) cells |
| Expression Pattern | up-regulated |
| Function Description | XIST was frequently upregulated while miR-429 was commonly downregulated in PC tissues, especially in metastatic PC tissues.Knockdown of XIST in two PC cell lines caused inhibition of migration, invasion and EMT capacities.Forced expression of miR-429 exerted the similar tumor suppressing effects. XIST repressed miR-429 expression thus upregulated ZEB1, one of the targets of miR-429. |
| Pubmed ID | 31163263 |
| Year | 2019 |
| Title | LncRNA XIST Promotes Pancreatic Cancer Migration, Invasion and EMT by Sponging miR-429 to Modulate ZEB1 Expression |
External Links
| Links for XIST | GenBank HGNC NONCODE |
| Links for pancreatic cancer | OMIM COSMIC |