Basic Information
| LncRNA/CircRNA Name | XIST |
| Synonyms | X inactivate-specific transcript |
| Region | GRCh38_X:73820651-73852753 |
| Ensemble | ENSG00000229807 |
| Refseq | NR_001564 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | nasopharyngeal cancer |
| ICD-0-3 | C11 |
| Methods | RT-qPCR, Western blot assay, Luciferase reporter assay, RIP |
| Sample | NPC tissues,NPC cell lines SUNE-1, CNE-1, CNE-2, C666-1, and HNE1 |
| Expression Pattern | up-regulated |
| Function Description | XIST was upregulated and miR-148a-3p was downregulated in NPC tissues and cell lines. Both XIST knockdown and miR-148a-3p overexpression promoted apoptosis, suppressed cell proliferation, migration, invasion, and EMT of NPC cells in vitro. |
| Pubmed ID | 31810117 |
| Year | 2020 |
| Title | LncRNA XIST Knockdown Suppresses the Malignancy of Human Nasopharyngeal Carcinoma Through XIST/miRNA-148a-3p/ADAM17 Pathway in Vitro and in Vivo |
External Links
| Links for XIST | GenBank HGNC NONCODE |
| Links for nasopharyngeal cancer | OMIM COSMIC |