Basic Information
| LncRNA/CircRNA Name | XIST |
| Synonyms | X-inactive specific transcript |
| Region | GRCh38_X:73820651-73852753 |
| Ensemble | ENSG00000229807 |
| Refseq | NR_001564 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, Dual luciferase reporter assay, Western blotting |
| Sample | OC and paired normal tissue,ovarian surface epithelial cell line HOSEPiCs and human OC cell lines SKOV3, OVCAR3, PEO1, A2780, 3AO, and CAOV3 |
| Expression Pattern | down-regulated |
| Function Description | XIST was significantly downregulated in OC tissues and cell lines compared with the normal ovarian epithelial tissues and cells. XIST knockdown in OC cells significantly facilitated cell growth, migration, and invasion and inhibited apoptosis. In addition, silencing XIST also initiated epithelial-mesenchymal transition (EMT) and conferred cancer stem cell (CSC) survival in vitro. |
| Pubmed ID | 31930432 |
| Year | 2019 |
| Title | LncRNA XIST Inhibits Ovarian Cancer Cell Growth and Metastasis via Regulating miR-150-5p/PDCD4 Signaling Pathway |
External Links
| Links for XIST | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |