Basic Information
| LncRNA/CircRNA Name | CASC2 |
| Synonyms | CASC2, C10orf5 |
| Region | GRCh38_10:118046279-118210153 |
| Ensemble | ENSG00000177640 |
| Refseq | NR_026939 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Cell transfection, Flow cytometry assay etc. |
| Sample | NSCLC tissues, cell lines (A549, PC-9, and NCI-H1299) |
| Expression Pattern | down-regulated |
| Function Description | CASC2 expression was significantly downregulated in 92.1 % cancerous tissues compared with normal counterparts. The lower expression of CASC2 was remarkably correlated with advanced TNM stage and tumor size. Multivariate analyses found that CASC2 expression served as an independent predictor for overall survival of NSCLC. Moreover, overexpression of CASC2 significantly inhibited NSCLC cell proliferation both in vitro and in vivo. |
| Pubmed ID | 26790438 |
| Year | 2016 |
| Title | Low expression of long noncoding RNA CASC2 indicates a poor prognosis and regulates cell proliferation in non-small cell lung cancer. |
External Links
| Links for CASC2 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |