Basic Information
| LncRNA/CircRNA Name | WWTR1-AS1 |
| Synonyms | NA |
| Region | GRCh38_3:149657020-149661364 |
| Ensemble | ENSG00000241313 |
| Refseq | NR_040250 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | head and neck squamous cell carcinoma |
| ICD-0-3 | C76.0 |
| Methods | qRT-PCR , Western blot , in vitro knockdown etc. |
| Sample | HNSCC tissue compared with its paired adjacent nontumor tissue ,HNSCC cell lines (SCC4, SCC9, SCC25, FaDu, and Cal27) ,normal human oral keratinocytes (HOK) cell line |
| Expression Pattern | up-regulated |
| Function Description | Aberrant overexpression of WWTR1-AS1 in HNSCC samples showed a significant correlation between its higher expression levels and larger tumor size, cervical node metastasis, and poor prognosis.WWTR1-AS1 knockdown mediated by antisense oligonucleotide markedly inhibited cell proliferation, migration, invasion, tumorsphere formation as well as apoptosis resistance probably by modulating WWTR1 messenger RNA (mRNA) stability in HNSCC cells.WWTR1-AS1 expression positively correlated with WWTR1 expression in TCGA-HNSCC data sets. |
| Pubmed ID | 31172583 |
| Year | 2019 |
| Title | Overexpression of lncRNA WWTR1-AS1 Associates With Tumor Aggressiveness and Unfavorable Survival in Head-Neck Squamous Cell Carcinoma |
External Links
| Links for WWTR1-AS1 | GenBank HGNC NONCODE |
| Links for head and neck squamous cell carcinoma | OMIM COSMIC |