Basic Information
| LncRNA/CircRNA Name | WT1-AS |
| Synonyms | WT1-AS, WIT-1, WIT1, WT1-AS1, WT1AS |
| Region | GRCh38_11:32435518-32458769 |
| Ensemble | ENSG00000183242 |
| Refseq | NR_023920 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | wilms tumor |
| ICD-0-3 | C64.9 |
| Methods | qPCR, RNAi, Southern blot etc. |
| Sample | Wilms tumor tissues |
| Expression Pattern | differential expression |
| Function Description | Our demonstration of CTCF involvement in AWT1/WT1-AS regulation, allied with the documented genetic lesions of chromosome 16q during Wilms' tumourigenesis, suggested the possibility of epigenetic deregulation at 11p13 arising due to 16q LOH. |
| Pubmed ID | 17210670 |
| Year | 2007 |
| Title | A CTCF-binding silencer regulates the imprinted genes AWT1 and WT1-AS and exhibits sequential epigenetic defects during Wilms' tumourigenesis. |
External Links
| Links for WT1-AS | GenBank HGNC NONCODE |
| Links for wilms tumor | OMIM COSMIC |