Basic Information
| LncRNA/CircRNA Name | WT1-AS |
| Synonyms | NA |
| Region | GRCh38_11:32435518-32458769 |
| Ensemble | ENSG00000183242 |
| Refseq | NR_023920 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, Western blot, RIP, luciferase reporter assay etc. |
| Sample | CC tissues and adjacent normal tissues, cell lines (HeLa, Caski,Ect1/E6E7) |
| Expression Pattern | down-regulated |
| Function Description | WT1-AS was downregulated in cervical tissues and cell lines. WT1-AS was predominantly located in the cytoplasm of CC cells. Upregulation of WT1-AS promoted cell apoptosis, blocked cell cycle, migration, invasion, and EMT in vitro. |
| Pubmed ID | 32319820 |
| Year | 2020 |
| Title | Long Noncoding RNA WT1-AS Inhibits the Progression of Cervical Cancer by Sponging miR-205. |
External Links
| Links for WT1-AS | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |