Basic Information
| LncRNA/CircRNA Name | UCA1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Hepatocellular Carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qRT-PCR, Western blotting, in vitro knockdown, RIP etc. |
| Sample | Human hepatocellular carcinoma Huh7 and HeG2 cells |
| Expression Pattern | up-regulated |
| Function Description | UPF1 expression was significantly reduced in hepatocellular carcinoma (HCC) tissues compared with the adjacent normal tissues. And further functional assays revealed that knockdown of UPF1 promoted HCC cells growth and invasion. Furthermore, we found that UPF1 could bind to long non-coding RNA urothelial cancer associated 1 (UCA1) and was negatively correlated with UCA1. UCA1 expression also affected HCC growth and invasion. Knockdown of UCA1 ameliorated the effect of UPF1 knock down on HCC growth and invasion. Knockdown of UPF1 enhances glycolysis in HCC. |
| Pubmed ID | 31040354 |
| Year | 2019 |
| Title | UPF1 Inhibits the Hepatocellular Carcinoma Progression by Targeting Long Non-Coding RNA UCA1 |
External Links
| Links for UCA1 | GenBank HGNC NONCODE |
| Links for Hepatocellular Carcinoma | OMIM COSMIC |