Basic Information
| LncRNA/CircRNA Name | UPAT |
| Synonyms | AOC4P, AOC4, UPAT |
| Region | GRCh38_17:42865922-42874369 |
| Ensemble | ENSG00000260105 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | qPCR, RNAi, RIP, RNA pull-down assay etc. |
| Sample | cell lines (HCT116, DLD-1, RKO, HAEC, HaCaT and 293FT) |
| Expression Pattern | up-regulated |
| Function Description | Here we show that an lncRNA termed UPAT is required for the survival and tumorigenicity of colorectal cancer cells. UPAT expression was up-regulated in highly tumorigenic colon cancer cell lines compared with weakly tumorigenic colon cancer cell lines and normal cell lines. UPAT interacts with and stabilizes the epigenetic factor UHRF1 by interfering with its B-transducin repeat-containing protein (TrCP)-mediated ubiquitination. Furthermore, we demonstrate that UHRF1 up-regulates Stearoyl-CoA desaturase 1 and Sprouty 4, which are required for the survival of colon tumor cells. |
| Pubmed ID | 26768845 |
| Year | 2016 |
| Title | Long noncoding RNA UPAT promotes colon tumorigenesis by inhibiting degradation of UHRF1. |
External Links
| Links for UPAT | GenBank HGNC NONCODE |
| Links for colon cancer | OMIM COSMIC |