Basic Information
LncRNA/CircRNA Name | UNC5B-AS1 |
Synonyms | NA |
Region | GRCh38_10:71217224-71218228 |
Ensemble | ENSG00000237512 |
Refseq | NR_038453 |
Classification Information
Regulatory Mechanism | Biological Function | Clinical Application | |||
---|---|---|---|---|---|
TF | Immune | Survival | |||
Enhancer | Apoptosis | apoptosis | Drug | ||
Variant | Cell Growth | Circulating | |||
MiRNA | EMT | Metastasis | |||
Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
Cancer Name | prostate cancer |
ICD-0-3 | C61.9 |
Methods | Luciferase reporter assay etc |
Sample | PCa tissue ,cell lines (PC-3, DU-145,22RV1, Lncap) |
Expression Pattern | up-regulated |
Function Description | RT-PCR results suggested that UNC5B-AS1 expression in PCa tissue samples was remarkably higher than in adjacent ones, with a statistically significant difference. Compared with patients with low expression of UNC5B-AS1, patients with highly-expressed UNC5B-AS1 had a higher incidence of distant metastasis and more advanced pathological stage. |
Pubmed ID | 32196578 |
Year | 2020 |
Title | LncRNA UNC5B-AS1 Promotes Malignant Progression of Prostate Cancer by Competitive Binding to caspase-9 |
External Links
Links for UNC5B-AS1 | GenBank HGNC NONCODE |
Links for prostate cancer | OMIM COSMIC |