Basic Information
| LncRNA/CircRNA Name | UCA1 |
| Synonyms | UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 |
| Region | GRCh38_19:15828206-15836326 |
| Ensemble | ENSG00000214049 |
| Refseq | NR_015379 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qPCR, RNAi, Luciferase reporter assay etc. |
| Sample | cell lines (5637, T24, BLZ-211, BLS-211) |
| Expression Pattern | up-regulated |
| Function Description | In the present study, we showed that lncRNA-UCA1 expression in bladder cancer cells was upregulated by transcription factor CCAAT/enhancer binding protein a (C/EBPa), The transcriptional activation of lncRNA-UCA1 by C/EBPa also contributes to the increased viability and decreased apoptosis of bladder cancer cells. |
| Pubmed ID | 24648007 |
| Year | 2014 |
| Title | Upregulation of long non-coding RNA urothelial carcinoma associated 1 by CCAAT/enhancer binding protein a contributes to bladder cancer cell growth and reduced apoptosis. |
External Links
| Links for UCA1 | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |