Basic Information
| LncRNA/CircRNA Name | UCA1 |
| Synonyms | UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 |
| Region | GRCh38_19:15828206-15836326 |
| Ensemble | ENSG00000214049 |
| Refseq | NR_015379 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, RNAi, Western blot, RIP, ChIP, Flow cytometry assay etc. |
| Sample | HCC tissues, cell lines (LO2-HBx, Hep3B and HepG2) |
| Expression Pattern | up-regulated |
| Function Description | UCA1 expression was significantly higher in HBx positive group as compared with HBx negative group. The level of UCA1 was positively correlated with the mRNA level of HBx in the HCC tissues. We also found the cells showed a markedly reduced proliferation rate when UCA1 was knocked down by specific siRNAs in LO2-HBx, Hep3B and HepG2 cells. Knockdown of UCA1 or HBx resulted in a significant reduction in the percentage of cells in the S phases and increased cell percentages in the G1 phases in LO2-HBx and Hep3B cells indicating a contribution of UCA1 in G1/S transition. |
| Pubmed ID | 27009634 |
| Year | 2016 |
| Title | HBx-upregulated lncRNA UCA1 promotes cell growth and tumorigenesis by recruiting EZH2 and repressing p27Kip1/CDK2 signaling. |
External Links
| Links for UCA1 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |