Basic Information
| LncRNA/CircRNA Name | UCA1 |
| Synonyms | UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 |
| Region | GRCh38_19:15828206-15836326 |
| Ensemble | ENSG00000214049 |
| Refseq | NR_015379 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR etc. |
| Sample | plasma, gastric cancer tissues |
| Expression Pattern | up-regulated |
| Function Description | We further analyzed the expression of the top 2 downregulated and up-regulated lncRNAs in 20 GC tissues and corresponding nontumourous tissues by qRT-PCR. The expression of HIF1A-AS1 and PVT1 drastically decreased in GC tumor tissues. Conversely, the expression of CBR3-AS1 and UCA1 increased. Moreover, UCA1 expression also increased in plasma from GC patients and a positive correlation was noted between GC tissues and plasma. |
| Pubmed ID | 26722487 |
| Year | 2015 |
| Title | Long non-coding RNA UCA1 may be a novel diagnostic and predictive biomarker in plasma for early gastric cancer. |
External Links
| Links for UCA1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |