Basic Information
| LncRNA/CircRNA Name | UCA1 |
| Synonyms | UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 |
| Region | GRCh38_19:15828206-15836326 |
| Ensemble | ENSG00000214049 |
| Refseq | NR_015379 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot, Northern blot, Flow cytometry assay etc. |
| Sample | cell lines (MCF-7, MDA-468) |
| Expression Pattern | up-regulated |
| Function Description | Results from Northern blot analysis indicated that CUDR was detectable only in human placenta but not in other normal tissues. For expression in human cancer cells, CUDR was detected in most cells of different tissue origins. CUDR mRNA was detected in human hepatocellular carcinoma HepG2 and Hep3B cells, human breast carcinoma MCF-7 and MDA-468 cells, human squamous carcinoma HeLa cells, human colon carcinoma HT-29 and CaCO-2 cells, as well as human lung carcinoma Calu-6 cells. However, CUDR was barely detectable in human prostate carcinoma PC3 cells. The differential expression of CUDR between human normal and cancer tissues is further demonstrated in tissues from cancer patients. |
| Pubmed ID | 17416635 |
| Year | 2007 |
| Title | Induction of drug resistance and transformation in human cancer cells by the noncoding RNA CUDR. |
External Links
| Links for UCA1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |