Basic Information
| LncRNA/CircRNA Name | UCA1 |
| Synonyms | UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 |
| Region | GRCh38_19:15828206-15836326 |
| Ensemble | ENSG00000214049 |
| Refseq | NR_015379 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | Microarray, qPCR, RNAi, Western blot, RIP, Luciferase reporter assay etc. |
| Sample | cell lines (MCF-7, MDA-MB-231, HCT-116 p53-WT, HCT-116 etc.) |
| Expression Pattern | up-regulated |
| Function Description | We found that UCA1 was upregulated in breast tumors compared with the normal breast tissue. In contrast, p27 was downregulated in breast tumors, which was derived from the same core. This negative correlation between UCA1 and p27 was further supported by the data from breast cancer TMA. |
| Pubmed ID | 24457952 |
| Year | 2014 |
| Title | Long non-coding RNA UCA1 promotes breast tumor growth by suppression of p27 (Kip1). |
External Links
| Links for UCA1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |