Basic Information
| LncRNA/CircRNA Name | UCA1 |
| Synonyms | UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 |
| Region | GRCh38_19:15828206-15836326 |
| Ensemble | ENSG00000214049 |
| Refseq | NR_015379 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR etc. |
| Sample | CRC tissues, cell lines (CaCO-2, SW480, HCT116, LoVo etc.) |
| Expression Pattern | up-regulated |
| Function Description | UCA1 levels were markedly increased in CRC tissues, and this high level of UCA1 expression was significantly correlated with larger tumour size, less differentiated histology and greater tumour depth. an important role for UCA1 in the molecular aetiology of CRC and suggest a potential application for UCA1 in CRC diagnosis, progression and therapy. |
| Pubmed ID | 24977734 |
| Year | 2014 |
| Title | UCA1, a long non-coding RNA up-regulated in colorectal cancer influences cell proliferation, apoptosis and cell cycle distribution. |
External Links
| Links for UCA1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |