Basic Information
| LncRNA/CircRNA Name | CASC2 |
| Synonyms | NA |
| Region | GRCh38_10:118046279-118210153 |
| Ensemble | ENSG00000177640 |
| Refseq | NR_026939 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | nasopharyngeal cancer |
| ICD-0-3 | C11 |
| Methods | qPCR, Luciferase reporter assay, RIP, etc. |
| Sample | NPC tissues, Normal nasopharyngeal epithelial cells (N69) and NPC cell lines (SUNE1, SUNE2 and 6-10B) |
| Expression Pattern | down-regulated |
| Function Description | CASC2 level is reduced in NPC tissues and cells. CASC2 downregulation promoted proliferation and inhibited apoptotic cell death in NPC cells. In contrast, CASC2 upregulation inhibited proliferation and increased apoptosis. There were putative binding sites of microRNA (miR) 18a 5p in the promoter of CASC2. The level of miR 18a 5p was upregulated in NPC tissues and cells. We further confirmed that CASC2 could directly bind with miR 18a 5p and inhibit miR 18a 5p expression, using reporter gene and RNA immunoprecipitation assays. miR 18a 5p suppressed CASC2 upregulation mediated decrease in proliferation and increase in apoptotic cell death. Bioinformatics predicted the putative binding site of miR 18a 5p in the 3' untranslated region of C terminal binding protein interacting protein (CtIP)/RBBP8. It was further confirmed that miR 18a 5p could directly bind with RBBP8 and inhibit RBBP8 expression. Downregulation of RBBP8 inhibited the anti miR 18a 5p mediated increase in apoptosis and decrease in proliferation. Downregulation of CASC2 increased tumor growth, increased the level of miR 18a 5p and decreased RBBP8 expression in vivo. In summary, CASC2 regulates NPC malignancy through modulation of RBBP8 via sponging miR 18a 5p. Our findings highlight the CASC2/miR 18a 5p/RBBP8 axis in NPC pathogenesis and provide new biomarkers and potential targets for the therapy of NPC |
| Pubmed ID | 30569153 |
| Year | 2019 |
| Title | lncRNA CASC2/miR-18a-5p axis regulates the malignant potential of nasopharyngeal carcinoma by targeting RBBP8 |
External Links
| Links for CASC2 | GenBank HGNC NONCODE |
| Links for nasopharyngeal cancer | OMIM COSMIC |