Basic Information
| LncRNA/CircRNA Name | UCA1 |
| Synonyms | UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 |
| Region | GRCh38_19:15828206-15836326 |
| Ensemble | ENSG00000214049 |
| Refseq | NR_015379 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, RNAi, Western blot, Cell proliferation assay etc. |
| Sample | glioma tissues, cell lines (U87, U251, SHG44, U373-MG) |
| Expression Pattern | up-regulated |
| Function Description | UCA1 expression in the glioma samples was obviously higher as compared with the normal brain samples, and the expression was correlated significantly with grading of the tumors. After interference of UCA1 expression by siRNA transfection, the proliferation of both U251 and SHG-44 cells was inhibited, with more cells arrested in G0/G1. Moreover, cyclin D1 expression was also downregulated considerably. |
| Pubmed ID | 28105536 |
| Year | 2017 |
| Title | A long noncoding RNA UCA1 promotes proliferation and predicts poor prognosis in glioma. |
External Links
| Links for UCA1 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |