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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	lung cancer
ICD-0-3	C34
Methods	qPCR, Western blot, Northern blot, Flow cytometry assay etc.
Sample	cell line (Calu-6)
Expression Pattern	up-regulated
Function Description	Results from Northern blot analysis indicated that CUDR was detectable only in human placenta but not in other normal tissues. For expression in human cancer cells, CUDR was detected in most cells of different tissue origins. CUDR mRNA was detected in human hepatocellular carcinoma HepG2 and Hep3B cells, human breast carcinoma MCF-7 and MDA-468 cells, human squamous carcinoma HeLa cells, human colon carcinoma HT-29 and CaCO-2 cells, as well as human lung carcinoma Calu-6 cells. However, CUDR was barely detectable in human prostate carcinoma PC3 cells. The differential expression of CUDR between human normal and cancer tissues is further demonstrated in tissues from cancer patients. Using PCR to compare the CUDR level between matched normal and tumor cDNA samples from the patient, it was indicated that CUDR was up-regulated in various tumor tissues: colon (five out of five), cervix (one out of one), and lung (four out of five), in comparison with respective normal tissue counterparts
Pubmed ID	17416635
Year	2007
Title	Induction of drug resistance and transformation in human cancer cells by the noncoding RNA CUDR.

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