Basic Information
| LncRNA/CircRNA Name | UCA1 |
| Synonyms | UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 |
| Region | GRCh38_19:15828206-15836326 |
| Ensemble | ENSG00000214049 |
| Refseq | NR_015379 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | luciferase reporter assay, qPCR, western blot etc. |
| Sample | cell lines (WI-38, HEL-1) |
| Expression Pattern | up-regulated |
| Function Description | This result indicated that the up-regulated expression of lncRNA UCA1 was involved in the canceration of normal lung cells. These findings will be helpful for understanding the critical roles of lncRNA UCA1 and miRNA-144 in lung cancer cells, and provide new therapeutic strategy for lung cancer therapy.The experimental study from Cheng et al. demonstrated that lncRNA UCA1 promoted non-T790M cells acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) by activating the AKT/mammalian target of rapamycin (mTOR) pathway in EGFR-mutant NSCLC. |
| Pubmed ID | 28762326 |
| Year | 2017 |
| Title | Long Noncoding RNA Urothelial Carcinoma Associated 1 Promotes the Proliferation and Metastasis of Human Lung Tumor Cells by Regulating MicroRNA-144 |
External Links
| Links for UCA1 | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |