Basic Information
| LncRNA/CircRNA Name | UCA1 |
| Synonyms | UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 |
| Region | GRCh38_19:15828206-15836326 |
| Ensemble | ENSG00000214049 |
| Refseq | NR_015379 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR etc. |
| Sample | cervical cancer tissues |
| Expression Pattern | up-regulated |
| Function Description | HOTAIR and UCA1 both were significantly higher expressed in GC tumor tissues than adjacent non-tumor tissues.The results from the qRT-PCR validation in 82 newly diagnosed GC patients and the above bioinformatics results were 100% in agreement. To further analyze the association between the 2 key lncRNAs and clinicopathological characteristics of 82 GC patients, we found that HOTAIR was significantly associated with tumor size and lymphatic metastasis, and UCA1 was significantly associated with tumor size,TNM stage and lymphatic metastasis. HOTAIR and UCA1 were found to be significantly associated with overall survival.The miR-1 was downexpressed when lncRNA UCA1 was overexpressed in glioma cells.mRNA XIRP1 was found to interact with miRNA miR-133a-3p. Key miRNA miR-133a-3p was predicted to target key lncRNA HOTAIR. |
| Pubmed ID | 29620291 |
| Year | 2018 |
| Title | Integrated analysis of long non-coding RNA competing interactions revealed potential biomarkers in cervical cancer: Based on a public database. |
External Links
| Links for UCA1 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |