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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	epithelial ovarian cancer
ICD-0-3	C56.9
Methods	qPCR, other
Sample	EOC tissues and cell lines (SKOV3, OV90,A2780, ES2 and IGROV-1)
Expression Pattern	down-regulated
Function Description	Analysis of association between clinicopathological features and CASC2 expression levels suggested that low CASC2 expression is associated with the serous histological subtype, lymph node metastasis , poor histological grade and large tumor size in EOC. Furthermore, low CASC2 expression predicted poor overall survival and progression-free survival. Functional assays, including Cell Counting kit-8 assays, colony formation assays, and Transwell and Matrigel assays, confirmed that silencing of CASC2 promoted the proliferation, migration and invasion of EOC cells; whereas, ectopic overexpression of CASC2 suppressed the proliferation, migration and invasion of EOC cells. In addition, in the analysis of the risk factors for poor prognosis, low CASC2 expression was identified as an independent risk factor for reduced overall survival progression-free survival in patients with EOC.
Pubmed ID	30320385
Year	2018
Title	Long Non-coding RNA CASC2 Inhibits Progression and Predicts Favorable Prognosis in Epithelial Ovarian Cancer

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