Basic Information
| LncRNA/CircRNA Name | UCA1 |
| Synonyms | UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 |
| Region | GRCh38_19:15828206-15836326 |
| Ensemble | ENSG00000214049 |
| Refseq | NR_015379 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | epithelial ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, RNAi, RIP, Luciferase reporter assay etc. |
| Sample | ovarian cancer tissues, cell lines (OMC685, A2780, and SKOV3) |
| Expression Pattern | up-regulated |
| Function Description | The results demonstrated that UCA1 expressions were markedly upregulated in cancer tissues than that in normal tissues. Findings of this study confirmed that not only UCA1 was aberrantly upregulated in EOC tissues and cells, but also correlated with status of lymph node metastasis and FIGO stage. Furthermore, univariate and multivariate analyses showed that UCA1 was a prognostic factor for overall survival in EOC patients. In vitro, knockdown of UCA1 reduced the invasion and migration ability of EOC cells. |
| Pubmed ID | 26867765 |
| Year | 2016 |
| Title | UCA1 functions as a competing endogenous RNA to suppress epithelial ovarian cancer metastasis. |
External Links
| Links for UCA1 | GenBank HGNC NONCODE |
| Links for epithelial ovarian cancer | OMIM COSMIC |