Basic Information
| LncRNA/CircRNA Name | CASC2 |
| Synonyms | CASC2, C10orf5 |
| Region | GRCh38_10:118046279-118210153 |
| Ensemble | ENSG00000177640 |
| Refseq | NR_026939 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 |
| Methods | qPCR, RIP, Western blot, Luciferase reporter assay, other |
| Sample | neoplastic tissues and lung epithelial cell line (BEAS-2B) |
| Expression Pattern | down-regulated |
| Function Description | Changing the levels of CASC2 and miR-4735-3p in the cultured adenocarcinoma cells could affect the malignant phenotypes as well as growth of tumors derived from the cells injected into nude mice. Furthermore, the lncRNA and miR-4735-3p interplay likely the suppressed tumor growth through the downstream mammalian target of rapamycin signaling pathway. |
| Pubmed ID | 30450692 |
| Year | 2018 |
| Title | LncRNA CASC2 Inhibits Proliferation and Migration of Adenocarcinoma Cells via miR-4735-3p and mTOR |
External Links
| Links for CASC2 | GenBank HGNC NONCODE |
| Links for lung adenocarcinoma | OMIM COSMIC |