Basic Information
| LncRNA/CircRNA Name | UCA1 |
| Synonyms | UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 |
| Region | GRCh38_19:15828206-15836326 |
| Ensemble | ENSG00000214049 |
| Refseq | NR_015379 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | exosome | ||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qPCR, Western blot |
| Sample | Human bladder cancer cell lines (5637, UMUC2 and T24) |
| Expression Pattern | down-regulated |
| Function Description | To explore the circulating exosomal lncRNA-UCA1, we isolated exosomes from the serum of bladder cancer patients and matched healthy donors.Hence, it is necessary to explore the precise mechanism that how cancer cells reshape their surrounding microenvironment under hypoxic conditions. Several studies have described that exosomal proteins and miRNAs derived from hypoxic tumor cells are transferred or delivered to modulate biological function and cell signaling of recipient cells [19, 31, 32]. |
| Pubmed ID | 28841829 |
| Year | 2017 |
| Title | Hypoxic exosomes facilitate bladder tumor growth and development through transferring long non-coding RNA-UCA1. |
External Links
| Links for UCA1 | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |