Basic Information
LncRNA/CircRNA Name | CASC2 |
Synonyms | CASC2, C10orf5 |
Region | GRCh38_10:118046279-118210153 |
Ensemble | ENSG00000177640 |
Refseq | NR_026939 |
Classification Information
Regulatory Mechanism | Biological Function | Clinical Application | |||
---|---|---|---|---|---|
TF | Immune | Survival | |||
Enhancer | Apoptosis | Drug | |||
Variant | Cell Growth | Circulating | |||
MiRNA | EMT | Metastasis | |||
Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
Cancer Name | oral squamous cell carcinoma |
ICD-0-3 | C06.9 |
Methods | qPCR, other |
Sample | OSCC tissue and cell lines(SCC090 and SCC25), plasma |
Expression Pattern | down-regulated |
Function Description | We found that CASC2 was significantly downregulated in OSCC patients than in healthy controls. Downregulation of CASC2 distinguished OSCC patients from healthy controls. Local recurrence was observed in 26 out of 122 patients and no distant recurrence was observed during follow-up. Compared with pretreatment levels, plasma levels of CASC2 were significantly increased in patients with local recurrence than in patients without recurrence. Transfection of CASC2 expression vectors led to significantly inhibited tumor cell proliferation and reduced miRNA-21 expression levels. |
Pubmed ID | 30467776 |
Year | 2019 |
Title | Downregulation of lncRNA CASC2 Promotes the Postoperative Local Recurrence of Early Oral Squamous Cell Carcinoma |
External Links
Links for CASC2 | GenBank HGNC NONCODE |
Links for oral squamous cell carcinoma | OMIM COSMIC |