Basic Information
| LncRNA/CircRNA Name | UCA1 |
| Synonyms | UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 |
| Region | GRCh38_19:15828206-15836326 |
| Ensemble | ENSG00000214049 |
| Refseq | NR_015379 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | tongue cancer |
| ICD-0-3 | C02 |
| Methods | qPCR, Luciferase reporter assay, RIP, etc. |
| Sample | ongue cancer tissue, Human tongue cancer cell lines, CAL-27 and SCC-9 |
| Expression Pattern | up-regulated |
| Function Description | UCA1 was overexpressed in tongue cancer tissues and cell lines. UCA1 overexpression was correlated to the poorer prognosis of patients with tongue cancer. UCA1 knockdown significantly suppressed TGF?1 induced tongue cancer cell invasion and EMT by decreasing vimentin and increasing E cadherin. Regarding the molecular mechanism, UCA1 could directly bind to micro- RNA 124 (miR 124) and negatively regulate each other. UCA1 knockdown ameliorated, whereas miR 124 inhibition exacerbated TGF?1 induced EMT and invasion in tongue cancer cells through miR 124 downstream jagged 1 (JAG1) and Notch signaling. Moreover, miR 124 inhibition partially impaired the effect of UCA1 knockdown. In tongue cancer tissues, miR 124 expression was remarkably decreased, whereas JAG1 mRNA expression was increased. miR 124 was negatively correlated with UCA1 and JAG1. UCA1 and JAG1 were positively correlated. |
| Pubmed ID | 30635938 |
| Year | 2019 |
| Title | LncRNA UCA1/miR-124 axis modulates TGF?1-induced epithelial-mesenchymal transition and invasion of tongue cancer cells through JAG1/Notch signaling. |
External Links
| Links for UCA1 | GenBank HGNC NONCODE |
| Links for tongue cancer | OMIM COSMIC |