Basic Information
| LncRNA/CircRNA Name | UCA1 |
| Synonyms | UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 |
| Region | GRCh38_19:15828206-15836326 |
| Ensemble | ENSG00000214049 |
| Refseq | NR_015379 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP, etc. |
| Sample | colon cancer tissues and benign colon cancer tissues, Human intestinal epithelial cell line NCM460 and human colon cancer cell lines (SW620, HT29, CACO2, SW480, and HCT116) |
| Expression Pattern | up-regulated |
| Function Description | UCA1 was upregulated in colon cancer tissues when compared with the adjacent nonhumorous tissues, as well as in the various colon cancer cell lines, but the expression of miR 28 5p showed an opposite trend. Furthermore, a high UCA1 level in colon cancer tissues is positively associated with the tumor size and advanced tumor stages. Functional assays revealed that both UCA1 knockdown and miR 28 5p overexpression could inhibit colon cancer cell growth and migration. Further mechanistic studies indicated that UCA1 knockdown played tumor suppressive roles in SW480 and HT116 cells through binding with miR 28 5p. |
| Pubmed ID | 30652355 |
| Year | 2019 |
| Title | LncRNA-UCA1 modulates progression of colon cancer through regulating the miR-28-5p/HOXB3 axis |
External Links
| Links for UCA1 | GenBank HGNC NONCODE |
| Links for colon cancer | OMIM COSMIC |