Basic Information
| LncRNA/CircRNA Name | UCA1 |
| Synonyms | UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 |
| Region | GRCh38_19:15828206-15836326 |
| Ensemble | ENSG00000214049 |
| Refseq | NR_015379 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | Microarray, qPCR, Western blot |
| Sample | cervical cancer tissues, cell lines(HEC251, HEC-1B, Hela, N3CA, HEC1A, RL95-2, Ishikawa3h12) |
| Expression Pattern | up-regulated |
| Function Description | UCA1 levels were higher in cancer tissues. The inhibition of UCA1 expression suppressed human cervical cancer cell proliferation and glycolysis. compared to matched adjacent normal tissues. our experimental results indicated that UCA1 could directly bind to miR-493-5p and regulate miR-493-5p expression in an inverse manner. |
| Pubmed ID | 31949782 |
| Year | 2018 |
| Title | Long Non-Coding RNA UCA1 Modulates the Glycolysis of Cervical Cancer Cells by miR-493-5p/HK2. |
External Links
| Links for UCA1 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |