Basic Information
| LncRNA/CircRNA Name | CASC2 |
| Synonyms | NA |
| Region | GRCh38_10:118046279-118210153 |
| Ensemble | ENSG00000177640 |
| Refseq | NR_026939 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qRT-PCR , Western blot etc. |
| Sample | cervical cancer tissues and para-cancerous tissues ,cervical cancer cell lines(HeLa and SiHa) ,immortalized human keratinocyte lines(HaCaT and HUVECs) |
| Expression Pattern | down-regulated |
| Function Description | CASC2 levels in human cervical cancer tissues and cell lines were significantly downregulated compared to para-cancerous tissues and the immortalized human keratinocyte line HaCaT.Compared to scramble group, CASC2 overexpression significantly inhibited the proliferation, migration, invasion, and angiogenesis of cervical cancer cells.However, the inhibition of CASC2 had the opposite effect. Moreover, the expression of p-JNK and p-ERK1 levels in the MAPK pathway was significantly decreased in pcDNA3.1-CASC2 group. |
| Pubmed ID | 31081078 |
| Year | 2019 |
| Title | Long Non-Coding RNA Cancer Susceptibility Candidate 2 Inhibits the Cell Proliferation, Invasion and Angiogenesis of Cervical Cancer Through the MAPK Pathway |
External Links
| Links for CASC2 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |