Basic Information
| LncRNA/CircRNA Name | UCA1 |
| Synonyms | UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 |
| Region | GRCh38_19:15828206-15836326 |
| Ensemble | ENSG00000214049 |
| Refseq | NR_015379 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | melanoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase assay |
| Sample | melanoma tissues, cell lines (WM266-4, A375, A2058, HS294T, NHEM) |
| Expression Pattern | up-regulated |
| Function Description | UCA1 expression was discovered to be up-regulated while miR-185-5p expression was down-regulated in melanoma tissues and cell lines. knockdown of UCA1 was found to suppress cell invasion through inhibiting EMT in melanoma. |
| Pubmed ID | 30144501 |
| Year | 2018 |
| Title | Long non-coding RNA UCA1 targets miR-185-5p and regulates cell mobility by affecting epithelial-mesenchymal transition in melanoma via Wnt/?-catenin signaling pathway. |
External Links
| Links for UCA1 | GenBank HGNC NONCODE |
| Links for melanoma | OMIM COSMIC |