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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	melanoma
ICD-0-3	NA
Methods	qRT-PCR, Western blotting, in vitro knockdown etc.
Sample	melanoma tumors and matched adjacent non-tumor tissues, normal human epidermal melanocyte HEMa-LP cells and human melanoma cell lines(A375, SK-MEL-2 and SK-MEL-28)
Expression Pattern	up-regulated
Function Description	UCA1 expression was increased in melanoma tissues and cell lines. In addition, UCA1 expression was higher in melanoma tissues at stage III-IV than in tissues at stage I-II. Inhibition of UCA1 expression markedly reduced melanoma cell proliferation and migration. Further investigation revealed that UCA1 functioned in melanoma cells through directly binding with microRNA (miR)-28-5p. The expression of miR-28-5p was significantly reduced in melanoma tissues and had an inverse correlation with UCA1 expression. In addition, miR-28-5p expression was higher in melanoma tissues at advanced stages than in stage I-II tissues. Furthermore, homeobox (HOX)B3 was identified as a target gene of miR-28-5p in melanoma cells, and HOXB3 overexpression reversed the suppressive effects of UCA1 downregulation on melanoma cell proliferation and migration. Finally, HOXB3 was upregulated in melanoma tissues compared with its expression in adjacent tissues, and HOXB3 expression was increased in melanoma tissues at advanced stages.
Pubmed ID	30988802
Year	2019
Title	Knockdown of lncRNA-UCA1 Inhibits the Proliferation and Migration of Melanoma Cells Through Modulating the miR-28-5p/HOXB3 Axis

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