Basic Information
| LncRNA/CircRNA Name | UCA1 |
| Synonyms | UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 |
| Region | GRCh38_19:15828206-15836326 |
| Ensemble | ENSG00000214049 |
| Refseq | NR_015379 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | Paclitaxel | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qRT-PCR , Microarray etc. |
| Sample | ovarian cancer tissues and normal tissues ,cell lines(SHIN3 SKOV3, RMG-1,?OVCAR3,?KFTX ,KFlow ,and KFTXlow ,A2780 cells,ES-2 cells,A549 cells ,SKOV3, RK13, and A549 cells) |
| Expression Pattern | up-regulated |
| Function Description | OVV was much more efficient in KFTX paclitaxel-resistant ovarian cancer cells compared to that in KFlow paclitaxel-sensitive cells.UCA1 was upregulation, which contributed to both enhanced paclitaxel resistance and OVV spread.In addition, UCA1 expression correlated with efficient OVV spread in other ovarian cell lines and primary cancer cell cultures.Paclitaxel exerted anti-tumor effects on KFlow, but not KFTX, tumors.In mice bearing KFTX cells after paclitaxel failure, OVV treatment induced the regression of residual tumors and improved survival. |
| Pubmed ID | 31011626 |
| Year | 2019 |
| Title | lncRNA UCA1-Mediated Cdc42 Signaling Promotes Oncolytic Vaccinia Virus Cell-to-Cell Spread in Ovarian Cancer |
External Links
| Links for UCA1 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |