Basic Information
| LncRNA/CircRNA Name | UCA1 |
| Synonyms | UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 |
| Region | GRCh38_19:15828206-15836326 |
| Ensemble | ENSG00000214049 |
| Refseq | NR_015379 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Western blot analysis, Luciferase assay |
| Sample | glioma tissues,glioma cell lines (U251, U87, A172, and SHG-44) and normal human astrocyte (NHA) cells |
| Expression Pattern | up-regulated |
| Function Description | lncRNA UCA1 was highly expressed in glioma tissues and cell lines. lncRNA UCA1 expression was associated with significantly poor overall survival in gliomas. Moreover, lncRNA UCA1 significantly enhanced cell proliferation and migration, and promoted the occurrence of EMT. In addition, lncRNA UCA1 promoted the development of EMT by positively regulating HOXD9 expression as a miR-135a sponge. In vivo experiments indicated that UCA1 exerted its biological functions by modulating miR-135a and HOXD9. |
| Pubmed ID | 31680311 |
| Year | 2020 |
| Title | 11 Long Noncoding RNA UCA1 Functions as miR-135a Sponge to Promote the Epithelial to Mesenchymal Transition in Glioma |
External Links
| Links for UCA1 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |