Basic Information
| LncRNA/CircRNA Name | UCA1 |
| Synonyms | UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 |
| Region | GRCh38_19:15828206-15836326 |
| Ensemble | ENSG00000214049 |
| Refseq | NR_015379 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, RNA-seq, RIP, Western blot Assay |
| Sample | primary gastric cancer tissues,GC cell lines (BGC-823, SGC-7901, and MGC803) and a normal gastric epithelium cell line (GES-1) |
| Expression Pattern | up-regulated |
| Function Description | upregulated UCA1 is associated with poor prognosis in gastric cancer patients. UCA1 knockdown significantly repressed the proliferation and migration both in vitro and in vivo. RNA sequencing (RNA-seq) analysis revealed that UCA1 knockdown preferentially affected genes that are linked to cell proliferation, cell cycle, and cell migration.UCA1 promotes cell proliferation progression through repressing p21 and Sprouty RTK signaling antagonist 1 (SPRY1) expression by binding to EZH2.UCA1 could mediate the trimethylation of H3K27 in promoters of p21 and SPRY1. |
| Pubmed ID | 31689615 |
| Year | 2019 |
| Title | lncRNA UCA1 Predicts a Poor Prognosis and Regulates Cell Proliferation and Migration by Repressing p21 and SPRY1 Expression in GC |
External Links
| Links for UCA1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |