Basic Information
| LncRNA/CircRNA Name | UCA1 |
| Synonyms | UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 |
| Region | GRCh38_19:15828206-15836326 |
| Ensemble | ENSG00000214049 |
| Refseq | NR_015379 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | Gefitinib | |
| Variant | Cell Growth | Circulating | 2 | ||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | Western blotting, qRT-PCR, Luciferase Reporter Assay, RIP |
| Sample | NSCLC tissues,serum samples,cell lines (HCC827 and PC9,16HBE) |
| Expression Pattern | up-regulated |
| Function Description | UCA1 promoted gefitinib resistance of NSCLC cells by packaging into exosomes. UCA1 knockdown impaired cell proliferation and promoted the gefitinib-induced cell apoptosis. repressed UCA1 promoted the miR-143 expression, and miR-143 could bind to the predicted binding site of UCA1. |
| Pubmed ID | 31951852 |
| Year | 2020 |
| Title | lncRNA UCA1 Promotes Gefitinib Resistance as a ceRNA to Target FOSL2 by Sponging miR-143 in Non-small Cell Lung Cancer |
External Links
| Links for UCA1 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |