Basic Information
| LncRNA/CircRNA Name | UCA1 |
| Synonyms | UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 |
| Region | GRCh38_19:15828206-15836326 |
| Ensemble | ENSG00000214049 |
| Refseq | NR_015379 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | autophagy | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | acute myeloid leukemia |
| ICD-0-3 | NA |
| Methods | qRT-PCR, western blot, luciferase reporter assays |
| Sample | Human AML cells (U937 and HL60) |
| Expression Pattern | up-regulated |
| Function Description | UCA1 promoted AML cell proliferation by inducing autophagy. UCA1 acted as a sponge of miR-96-5p by binding to miR-96-5p. ATG7 was a direct target of miR-96-5p and positively regulated by UCA1.UCA1 functions as a sponge of miR-96-5p to upregulate its target ATG7, thereby resulting in autophagy induction. |
| Pubmed ID | 31953866 |
| Year | 2020 |
| Title | Long Non-Coding RNA UCA1 Promotes Autophagy by Targeting miR-96-5p in Acute Myeloid Leukaemia |
External Links
| Links for UCA1 | GenBank HGNC NONCODE |
| Links for acute myeloid leukemia | OMIM COSMIC |