Basic Information
| LncRNA/CircRNA Name | CASC2 |
| Synonyms | cancer susceptibility candidate 2 |
| Region | GRCh38_10:118046279-118210153 |
| Ensemble | ENSG00000177640 |
| Refseq | NR_026939 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic cancer |
| ICD-0-3 | C25 |
| Methods | Dual luciferase reporter assay, RT-qPCR, Western blotting |
| Sample | pancreatic cancer tissues,pancreatic normal epithelial cell line hTERT-HPNE,pancreatic cancer cell lines AsPC-1 |
| Expression Pattern | down-regulated |
| Function Description | CASC2 and MUC6 were downregulated, and miR-24 was upregulated in pancreatic cancer specimens and cell lines. Functionally, CASC2 overexpression or miR-24 knockdown suppressed pancreatic cancer cell proliferation, colony formation, migration and invasion, and promoted apoptosis. Additionally, they altered cell-cell adhesion as demonstrated by the attenuated ITGB4, p-FAK and N-cadherin protein levels, as well as morphological changes. |
| Pubmed ID | 31894271 |
| Year | 2020 |
| Title | Long Non-coding RNA CASC2 Suppresses Pancreatic Cancer Cell Growth and Progression by Regulating the miR-24/MUC6 Axis |
External Links
| Links for CASC2 | GenBank HGNC NONCODE |
| Links for pancreatic cancer | OMIM COSMIC |