Basic Information
| LncRNA/CircRNA Name | UCA1 |
| Synonyms | UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 |
| Region | GRCh38_19:15828206-15836326 |
| Ensemble | ENSG00000214049 |
| Refseq | NR_015379 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, Western blot, in vitro knockdown |
| Sample | cervical cancer cell lines (HeLa and SiHa) |
| Expression Pattern | up-regulated |
| Function Description | Following the establishment of IRR cell lines (SiHa-IRR and HeLa-IRR), it was demonstrated that SiHa-IRR and HeLa-IRR cells exhibited increased expression levels of UCA1 and enhanced glycolysis. Dysregulation of UCA1 and inhibition of glycolysis affected radioresistance of cervical cancer cells. In addition, the results indicated that UCA1 promoted radioresistance-associated glycolysis in SiHa-IRR and HeLa-IRR cells, with the enzyme hexokinase 2 (HK2) acting as a significant regulator in this process. Inhibiting glycolysis by 2-DG reversed the effects of UCA1 overexpression on HK2 protein expression and radioresistance in SiHa and HeLa cells. |
| Pubmed ID | 30015920 |
| Year | 2018 |
| Title | Long Non-coding RNA Urothelial Cancer Associated 1 Regulates Radioresistance via the Hexokinase 2/glycolytic Pathway in Cervical Cancer |
External Links
| Links for UCA1 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |