Basic Information
| LncRNA/CircRNA Name | uc002mbe.2 |
| Synonyms | MIR7-3HG, C19orf30, Huh7, LINC00306, NCRNA00306, PGSF1, uc002mbe.2 |
| Region | GRCh38_19:4769140-4772533 |
| Ensemble | ENSG00000176840 |
| Refseq | NR_027148 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | liver cancer |
| ICD-0-3 | C22.0 |
| Methods | Microarray, qPCR etc. |
| Sample | liver cancer tissues, cell lines (Huh7, Bel7402, Bel7721, HepG2 etc.) |
| Expression Pattern | down-regulated |
| Function Description | Compared with normal human hepatocytes and adjacent noncancerous tissues, uc002mbe.2 expression level was significantly lower in the HCC cell lines and liver cancer tissues. The TSA-induced uc002mbe.2 expression was positively correlated with the apoptotic effect of TSA in HCC cells. Therefore, TSA-induced apoptosis of HCC cells is uc002mbe.2 dependent and reduced expression of uc002mbe.2 may be associated with liver carcinogenesis. |
| Pubmed ID | 23643933 |
| Year | 2013 |
| Title | Induction of the liver cancer-down-regulated long noncoding RNA uc002mbe.2 mediates trichostatin-induced apoptosis of liver cancer cells. |
External Links
| Links for uc002mbe.2 | GenBank HGNC NONCODE |
| Links for liver cancer | OMIM COSMIC |