Basic Information
| LncRNA/CircRNA Name | uc.57 |
| Synonyms | NA |
| Region | GRCh38_10:1526637-1556984 |
| Ensemble | ENSG00000205696 |
| Refseq | NR_033387 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | Shikonin, Tamoxifen | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot, RIP etc. |
| Sample | breast cancer tissues, cell line (MCF-7, MCF-7R) |
| Expression Pattern | down-regulated |
| Function Description | uc.57 binds to BCL11A. Uc.57 overexpression downregulated BCL11A and reduced tamoxifen resistance in MCF-7R cells both in vitro and in vivo. |
| Pubmed ID | 29179465 |
| Year | 2017 |
| Title | Shikonin reduces tamoxifen resistance through long non-coding RNA uc.57 |
External Links
| Links for uc.57 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |