Basic Information
| LncRNA/CircRNA Name | uc.38 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot, RIP |
| Sample | breast cancer tissues, cell lines (SUM1315, MCF-10A, MCF-7, ZR-75-1, BT-474, MDA-MB-231, SUM1315 and SK-BR-3) |
| Expression Pattern | down-regulated |
| Function Description | The expression of uc.38, a T-UCR, was down-regulated in both breast cancer tissues and breast cancer cell lines. uc.38 was expressed at significantly lower levels in larger tumours and tumours of more advanced stages.up-regulation of uc.38 expression inhibited cell proliferation and induced cell apoptosis.uc.38 suppressed breast cancer. uc.38 negatively regulated the expression of the pre-B-cell leukaemia homeobox 1 (PBX1) protein and subsequently affected the expression of Bcl-2 family members,ultimately inducing breast cancer cell apoptosis.The level of expression and type of TUCR have been shown to be closely related to the survival rates of patients with cancer. |
| Pubmed ID | 29312798 |
| Year | 2017 |
| Title | uc.38 induces breast cancer cell apoptosis via PBX1. |
External Links
| Links for uc.38 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |