Basic Information
| LncRNA/CircRNA Name | CASC19 |
| Synonyms | NA |
| Region | GRCh38_8:127072694-127227541 |
| Ensemble | ENSG00000254166 |
| Refseq | NR_120364 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Luciferase reporter assay |
| Sample | Bronchial cell line HBE and lung carcinoma cell lines (A549, H322, PC9, and GLC-B2), Tumor tissues and matched normal tissues, Tumor tissues and matched normal tissues |
| Expression Pattern | up-regulated |
| Function Description | LncRNA CASC19 was upregulated in NSCLC tissues and cell lines. NSCLC patients with high expression of CASC19 presented a worse survival. Knockdown of CASC19 attenuated proliferative, migratory, and invasive capacities of A549 and PC9 cells. CASC19 sponged miRNA-130b-3p and negatively regulated its level. ZEB2 was the direct target of miRNA-130b-3p. The knockdown of miRNA-130b-3p reversed the regulatory effects of CASC19 on A549 and PC9 cells. |
| Pubmed ID | 31389608 |
| Year | 2019 |
| Title | LncRNA CASC19 promotes the proliferation, migration and invasion of non-small cell lung carcinoma via regulating miRNA-130b-3p |
External Links
| Links for CASC19 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |