Basic Information
| LncRNA/CircRNA Name | CASC19 |
| Synonyms | NA |
| Region | GRCh38_8:127072694-127227541 |
| Ensemble | ENSG00000254166 |
| Refseq | NR_120364 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , RIP , in vitro knockdown etc. |
| Sample | human CRC tissues, pair-matched adjacent normal colon tissues ,healthy colon epithelial cell line (FHC) and CRC cell lines (HCT-116, SW480, Lovo, and SW620) |
| Expression Pattern | up-regulated |
| Function Description | CASC19 expression was markedly upregulated in CRC tissues and CRC cell lines.CASC19 expression was higher in 25 tissue samples from patients with aggressive CRC compared with the 27 tissue samples from patients with nonaggressive CRC.Higher CASC19 expression was associated with poorer patient prognoses.CASC19 overexpression enhanced CRC cell invasion, migration, and proliferation.CASC19 overexpression enhanced the expression of cell migration inducing hyaluronidase 1 (CEMIP) and epithelial-mesenchymal transition markers.CASC19 positively regulates CEMIP expression through targeting miR-140-5p. |
| Pubmed ID | 31011255 |
| Year | 2019 |
| Title | Functional Role of Long Non-Coding RNA CASC19/miR-140-5p/CEMIP Axis in Colorectal Cancer Progression?in vitro |
External Links
| Links for CASC19 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |