Basic Information
| LncRNA/CircRNA Name | u50535 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown |
| Sample | colorectal cancer,cell lines (HCT116, HCT8, DLD1, HCT15) |
| Expression Pattern | up-regulated |
| Function Description | We found a novel lncRNA u50535, which was greatly overexpressed in CRC tissues and was associated with poor prognosis in CRC patients. Chi-square tests revealed that high u50535 expression level is strongly correlated with the lymph node metastasis (P????.025), and TNM stage (P????.037). Function studies showed that u50535 was an oncogene in CRC both in vitro and in vivo. In mechanism, through RNA sequencing and rescue assay, we found that u50535 activates CCL20 signaling to promote cell proliferation and migration in CRC. u50535 enhances CRC cell proliferation, inhibits apoptosis and accelerates cell cycle. |
| Pubmed ID | 29970882 |
| Year | 2018 |
| Title | The Novel Long Noncoding RNA u50535 Promotes Colorectal Cancer Growth and Metastasis by Regulating CCL20 |
External Links
| Links for u50535 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |