Basic Information
| LncRNA/CircRNA Name | TUSC7 |
| Synonyms | TUSC7, LINC00902, LSAMP-AS1, LSAMP-AS3, LSAMPAS3, NCRNA00295 |
| Region | GRCh38_3:116709235-116723581 |
| Ensemble | ENSG00000243197 |
| Refseq | NR_015391 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Cell transfection, Western blot, Luciferase reporter assay, CCK-8 assay etc. |
| Sample | CRC tissues, cell lines (M5, DLD1, HCT116, SW480, SW620, and HT29) |
| Expression Pattern | down-regulated |
| Function Description | TUSC7 was significantly downregulated in CRC tissues. Ectopic expression of TUSC7 in HCT116 and SW480 cells significantly inhibited cell proliferation rate. Flow cytometry analyses revealed cycles were arrested at G1 phase after TUSC7 overexpression. We found there were 2 binding sites of miR-211-3p within the sequence of TUSC7 and TUSC7 expression level was negatively correlated with miR-211-3p. TUSC7 overexpression increased the expression level of CDK6, which is a downstream target of miR-211-3p, in both RNA and protein level. Furthermore, luciferase reporter assay indicated that TUSC7 could sponge miR-211-3p. |
| Pubmed ID | 28214867 |
| Year | 2017 |
| Title | The Novel Long Noncoding RNA TUSC7 Inhibits Proliferation by Sponging MiR-211 in Colorectal Cancer. |
External Links
| Links for TUSC7 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |