Basic Information
| LncRNA/CircRNA Name | TUSC7 |
| Synonyms | TUSC7, LINC00902, LSAMP-AS1, LSAMP-AS3, LSAMPAS3, NCRNA00295 |
| Region | GRCh38_3:116709235-116723581 |
| Ensemble | ENSG00000243197 |
| Refseq | NR_015391 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, RIP, Luciferase reporter assay, RNA pull-down assay, Cell proliferation assay etc. |
| Sample | glioma tissues, cell lines (U251, U87 and HEK 293T) |
| Expression Pattern | down-regulated |
| Function Description | TUSC7 was poorly expressed in tissues and cell lines of glioma, and the lower expression was correlated with glioma of the worse histological grade. Moreover, TUSC7 is a prognostic biomarker of glioma patients. Up-regulation of TUSC7 suppressed cellular proliferation and invasion of glioma cells, and accelerated cellular apoptosis. TUSC7 inhibited the proliferation, migration and invasion of glioma cells and promoted cellular apoptosis largely bypassing miR-23b. |
| Pubmed ID | 27766072 |
| Year | 2016 |
| Title | Long Non-coding RNA TUSC7, a Target of miR-23b, Plays Tumor-Suppressing Roles in Human Gliomas. |
External Links
| Links for TUSC7 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |