Basic Information
| LncRNA/CircRNA Name | TUSC7 |
| Synonyms | TUSC7, LINC00902, LSAMP-AS1, LSAMP-AS3, LSAMPAS3, NCRNA00295 |
| Region | GRCh38_3:116709235-116723581 |
| Ensemble | ENSG00000243197 |
| Refseq | NR_015391 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, RNAi, Western blot, Cell proliferation assay etc. |
| Sample | HCC tissues, cell lines (HepG2, MHCC97L, Hep3B, SMMC-7721, MHCC97H, and Huh7) |
| Expression Pattern | down-regulated |
| Function Description | In this study, we observed that the expression of TUSC7 was immensely decreased in HCC. Clinically, the lower expression of TUSC7 predicted poorer survival and may be an independent risk factor for HCC patients. Moreover, TUSC7 inhibited cell metastasis, invasion, and epithelial-to-mesenchymal transformation (EMT) through competitively binding miR-10a. Furthermore, we found that TUSC7 could decrease the expression of Eph tyrosine kinase receptor A4 (EphA4), a downstream target of miR-10a as well as an EMT suppressor, through TUSC7-miR-10a-EphA4 axis. |
| Pubmed ID | 27002617 |
| Year | 2016 |
| Title | Long non-coding RNA TUSC7 acts a molecular sponge for miR-10a and suppresses EMT in hepatocellular carcinoma. |
External Links
| Links for TUSC7 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |