Basic Information
| LncRNA/CircRNA Name | CASC15-S |
| Synonyms | CASC15, LINC00340, lnc-SOX4-1 |
| Region | GRCh38_6:21664772-22368328 |
| Ensemble | ENSG00000272168 |
| Refseq | NR_015410 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | neuroblastoma |
| ICD-0-3 | NA |
| Methods | RNA-seq, qPCR, RNAi, Luciferase reporter assay, RNA-FISH etc. |
| Sample | neuroblastoma cell lines |
| Expression Pattern | down-regulated |
| Function Description | Here we report that the most highly significant single-nucleotide polymorphism (SNP) associations reside within CASC15, a long noncoding RNA that we define as a tumor suppressor at 6p22. Low-level expression of a short CASC15 isoform (CASC15-S) associated highly with advanced neuroblastoma and poor patient survival. |
| Pubmed ID | 26100672 |
| Year | 2015 |
| Title | CASC15-S Is a Tumor Suppressor lncRNA at the 6p22 Neuroblastoma Susceptibility Locus. |
External Links
| Links for CASC15-S | GenBank HGNC NONCODE |
| Links for neuroblastoma | OMIM COSMIC |