Basic Information
| LncRNA/CircRNA Name | TUG1 |
| Synonyms | TUG1, LINC00080, NCRNA00080, TI-227H |
| Region | GRCh38_22:30969245-30979395 |
| Ensemble | ENSG00000253352 |
| Refseq | NR_002323 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, etc. |
| Sample | Human normal osteoblastic cell line (hFOB1), 4 human osteosarcoma cell lines (Saos-2, U2OS, HOS, MG63). |
| Expression Pattern | up-regulated |
| Function Description | We concluded that glycolysis was involved in the effect of TUG1 on cell viability of osteosarcoma cells. HK2 might be an important molecule by which TUG1 affected the glycolysis.In conclusion, TUG1 was overexpressed in the osteosarcoma cells and the abnormal expression of TUG1 affected cell viability. TUG1 regulated HK2 expression, which resulted in the change of glycolysis. The regulation of glycolysis may be an important mechanism by which TUG1 affected the viability of osteosarcoma cells. TUG1 elevated cell migration and invasion by working as a competitive endogenous RNA via miR-335-5p. |
| Pubmed ID | 29960067 |
| Year | 2018 |
| Title | LncRNA TUG1 affects cell viability by regulating glycolysis in osteosarcoma cells. |
External Links
| Links for TUG1 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |